Every Tuesday at this Center City Mexican cantina, comedians take the upstairs stage with sign-ups starting at 8:30 p.m. and sets beginning at 9:30 p.m. Jose Pistola's, which Philadelphia Magazine once named Best Bar for its "come-as-you-are attitude," keeps the kitchen open until 1 a.m.—so you can pair your laughs with creative tacos like tempura shrimp or cochinita pibil and $15 happy hour margarita pitchers.